Does tretinoin work on melasma ?


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TRETINOIN

What is tretinoin?

Tretinoin is one of a category of medications called retinoids.  It’s a form of vitamin A that acts on the skin by increasing skin cell production and turnover. Tretinoin boosts the exfoliation process, causing your skin cells to slough off and regenerate more quickly. 

What is it best for?

Topical tretinoin has a variety of uses in skin care products. Because it acts to increase cell production and slough off the outermost layer of skin cells, tretinoin is great for revealing an overall healthier complexion and more youthful skin with an even complexion. 

Tretinoin specifically can reduce the appearance of dark spots, liver spots, melasma, and hyperpigmentation. It is useful in treating sun damage in general to the face and neck and gives the skin a brighter, more uniform, and youthful color.

It is also used to treat acne by expelling comedones or clogged and infected pores. Rough, irritated skin flakes off and a healthier complexion is left in its place.

Because tretinoin promotes skin cell regeneration, it's also one of the best anti-aging ingredients out there.

What is the drawback?

Tretinoin comes with many skincare benefits, but it also has many drawbacks.

Because tretinoin works by sloughing off skin cells and regenerating new ones quickly, when you first start using it, you will likely have patches of redness, irritation, and flaky skin.  If you have acne, it may look and feel worse for a week or two because there have been blemishes and pore blockages forming in the deepest layers of your skin that are coming to the surface. People with skin sensitivities can experience severe irritation, redness, inflammation, and burning. It may take up to 8-12 weeks before your skin starts to look more healthy and youthful.

Another drawback to tretinoin is that it makes your skin more sensitive to sunlight and sunburn. Tretinoin is also not approved for use in anyone under 18 or for women who are pregnant or breast-feeding.

Because of the many drawbacks of tretinoin, it's only available via dermatologists' prescription or telemedicine brands, making it harder to get. 


MELASMA

What is melasma?

Melasma is a specific example of hyperpigmentation. Melasma looks like whole patches of brown or darker skin across the parts of the face and neck. Melasma is common among women who are pregnant - it’s even referred to as “the mask of pregnancy.”  But melasma can occur in both men and women who are not pregnant, too. Melasma can be caused by UV damage, but there are also genetic, hormonal, and medication-induced causes for melasma, too.

What ingredients are best for melasma?

There are a variety of topical ingredients that can be used to lighten the skin from melasma or reduce its appearance. Each ingredient works in different ways, and each has their own benefits and drawbacks.  hydroquinone, arbutin, vitamin C (ascorbic acid, and tetrahexyldecyl ascorbate, etc) are some of the most commonly used ingredients for melasma treatment. 

Hydroquinone is a skin lightening cream that works by suppressing the production of melanin. There are drawbacks to using hydroquinone, however, including cancer risks demonstrated by recent scientific studies, as well as  hydroquinone-induced ochronosis. 

Arbutin is a synthesized derivative of hydroquinone. It acts as a powerful skin lightening ointment that works a bit differently than hydroquinone. It blocks the production of melanin instead of “bleaching” the skin. 

Vitamin C can be used as a brightening agent to lighten the hyperpigmentation of your sunspots or melasma. It works by inhibiting the enzyme tyrosinase, preventing the formation of melatonin. 

Ascorbic Acid is actually the formal scientific name for one form of Vitamin C.  It can refer to either a naturally occurring Vitamin C found in foods such as citrus, or a synthetic form of ascorbic acid created to be more shelf-stable for skincare products like discoloration repair lotions and creams. 

Tetrahexyldecyl Ascorbate is another form of Vitamin C.  By synthesizing this compound from Vitamin C, dermatologists are able to give us all the benefits of Vitamin C in a more shelf-stable form that can also be soluble in oil to make more effective, deeper penetrating skin products.  (Herndon 2016)

Ingredients in the vitamin A family (ie. Retinol, tretinoin, etc) and acids (glycolic acid, lactic acid, salicylic acid) help damaged pigmented skin cells shred faster, so they also help with melasma. 


Does tretinoin work on melasma ?

tretinoin may be effective for melasma, but there are many other factors that may affect whether this ingredient would work on your skin or if there are better ingredients that may work for you. Take this skin quiz to find the best ingredients for your skin and build your skincare routine.


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